局部功能连接性减少与自闭症谱系障碍儿童的非典型表现相关
Fang Ye1, Pianpian Hu2,3, Aocai Yang2,4
1Department of Pediatrics, China-Japan Friendship Hospital, Beijing, 100029, China.
Brain imaging and behavior
|March 6, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童在特定的大脑区域的局部功能连接 (FC) 减少. 这种降低的FC与自闭症儿童的非典型行为和发育系数有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物医学工程 生物医学工程
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其特点是社会,沟通和行为异常.
- 了解ASD的神经基础,特别是局部功能连接 (FC),对于开发有针对性的干预措施至关重要.
- 以前的研究表明,在ASD中大脑连接性发生了广泛的改变,但局部FC模式及其行为相关性需要进一步调查.
研究的目的:
- 调查ASD儿童和典型发育 (TD) 儿童之间局部功能连接 (FC) 的差异.
- 探索局部FC测量与自闭症行为检查表 (ABC) 和吉塞尔发育诊断尺度 (GDDS) 评估的自闭症行为特征之间的关系.
主要方法:
- 招募了30名ASD儿童和25名TD儿童参加该研究.
- 使用静止状态功能磁共振成像 (rs-fMRI) 来测量区域同质性 (ReHo) 作为局部FC的指标.
- 用ABC来评估自闭症特异性行为和GDDS来评估发育分数的行为表现.
主要成果:
- 与TD儿童相比,患有ASD的儿童在右尾叶语言,左后中心和左前中显著减少了ReHo.
- 在ASD组中,左后中心和左前的较低的ReHo与较高的ABC总分数有关.
- 在左侧后中心和感觉/身体/物体使用,左侧前和社会/自助技能以及右叶语言和适应性/精细运动发展 (GDDS DQ) 中发现了ReHo之间的特定相关性.
结论:
- 患有自闭症的儿童在特定区域的功能性大脑连接中表现出局部减少.
- 这些局部FC变化与自闭症中观察到的独特的行为和发育特征有显著的关联.
- 这些发现为ASD背后的神经生物学机制提供了新的见解,并提出了潜在的干预目标.
相关概念视频
01:19Autism Spectrum Disorder
53
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
53
01:26Modeling in Therapy
39
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
39
01:30Attention-Deficit/Hyperactivity Disorder
34
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
34