在以人口为基础的分析中,在黑人和白人男性中具有中间风险的前列腺癌中,积极监测的利用和癌症控制结果
Shane A Tinsley1, Alex Stephens2, Chase Morrison3
1Vattikuti Urology Institute, Henry Ford Health, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Journal of racial and ethnic health disparities
|March 6, 2025
概括
在非西班牙裔黑人 (NHB) 和非西班牙裔白人 (NHW) 患者中,中等风险前列腺癌 (iPCa) 利用率的积极监测 (AS) 增加. 然而,与NHW患者相比,NHB患者的前列腺癌特异性死亡率 (PCSM) 风险明显更高.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 健康差异 在健康上的差异
背景情况:
- 积极监测 (AS) 是低风险前列腺癌 (PCa) 的管理策略.
- 了解AS使用和中等风险PCa (iPCa) 结果的种族差异至关重要.
研究的目的:
- 为了比较非西班牙裔黑人 (NHB) 和非西班牙裔白人 (NHW) iPCa.患者之间的AS和前列腺癌特异性死亡率 (PCSM) 的利用率.
- 确定与AS一起管理的ipca的结果中的潜在种族差异.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库 (2010-2016).
- 使用单变量和多变量逻辑回归计算AS率.
- 使用治疗权重的逆概率,竞争风险累积发病率函数和多变量分析来评估死亡风险.
主要成果:
- 从2010年至2016年,AS利用率在NHB和NHW患者中增加.
- 多变量分析显示,NHB种族与AS利用之间存在负相关性.
- 与NHW患者相比,NHB患者的PCSM风险显著更高 (HR 3.01),尽管其他原因死亡率 (OCM) 类似.
结论:
- 在不同种族群体中,对iCa的AS利用率有所上升.
- 与NHW患者相比,在AS管理的IPCa的NHB患者的PCSM风险不成比例地更高.
- 解决PCa结果中的种族差异对于公平的癌症护理至关重要.
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