在绝经后的妇女中,有意减肥,腰围减少和死亡风险
Michael Hendryx1, JoAnn E Manson2, Robert J Ostfeld3
1School of Public Health, Indiana University Bloomington.
JAMA network open
|March 6, 2025
概括
在女性中,有意减肥与腰围缩小相结合,与所有原因,癌症和心血管疾病的死亡率降低有关. 无意减肥会增加死亡风险.
科学领域:
- 老年学和流行病学.
- 心血管健康和瘤学研究.
- 公共卫生和预防医学.
背景情况:
- 减肥研究往往忽视了故意性,依赖于体重指数 (BMI),可能误解了健康风险.
- 区分有意与无意减肥对于理解死亡率相关性至关重要.
研究的目的:
- 为了研究故意减肥,腰围 (WC) 减少和死亡风险之间的关系.
- 评估通过自我报告和WC变化来衡量的有意减肥是否会影响所有原因,癌症和心血管死亡率.
主要方法:
- 来自妇女健康倡议观察研究中的58,961名女性 (50-79岁) 的前性队列研究.
- 随访时间平均为18.6年,从基线到第三年分析体重减轻和WC变化.
- 考克斯的比例危险回归模型评估了减肥,WC减少和死亡结果之间的关联.
主要成果:
- 蓄意减肥 (≥5磅) 与较低的全因,癌症和心血管死亡率有关.
- 蓄意减肥与测量 WC 减少相结合,显著降低了全因,癌症和心血管死亡率.
- 无意减肥或WC减肥,以及任何体重或WC增加,都与死亡风险增加有关.
结论:
- 蓄意减肥,特别是伴随着腰围缩小时,与死亡率降低有关.
- 建议通过饮食和运动促进有意减肥和减少中心脂肪的策略,以改善健康结果.
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