基于持续释放Risperidone的精神分裂症治疗从Poly (乳酸-co-glycolic) 酸植入式微型阵列补丁
Linlin Li1, Li Zhao1, Mingshan Li1
1School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.
ACS applied materials & interfaces
|March 6, 2025
概括
这项研究引入了一种新型的聚乳糖糖酸微针贴片,用于利斯佩里的输送,提供自给自取的长期精神分裂症治疗. 该贴片确保了持续的药物释放和治疗性血度,改善了患者的服药性,减少了医疗干预.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症影响全球2400万,目前的注射等治疗方法也有局限性.
- 治疗精神分裂症的传统药物输送方法可能会很痛苦,需要专业的管理.
- 需要改进的药物输送系统,提供持续释放和患者方便.
研究的目的:
- 开发和评估一种基于聚乳-可-甘油酸 (PLGA) 的植入式微针贴片 (IMN) 用于通过皮肤输送瑞斯 (RIS).
- 评估RIS装载IMN的机械性能,生物相容性和药物释放特征.
- 为了研究RIS IMN在老鼠模型中的体内疗效,与肌内注射相比.
主要方法:
- 基于PLGA的微针贴片的制造,装有Risperidone.
- 使用显微镜,差分扫描热量计和红外光谱学进行表征.
- 在小鼠体内药物释放,体外皮肤透,体外细胞相容性和体内药物动力学研究.
主要成果:
- 瑞士IMN显示出出色的机械性能和成功插入模型皮肤.
- 生物相容性研究没有显示对人类皮肤纤维细胞的细胞毒性.
- 试验室研究表明,在7天内持续释放RIS,其传递效率超过65%.
- 在体内研究表明,持续治疗性血度持续9天,超过肌内注射的短时间.
结论:
- 瑞士IMN提供了一个有前途的,自我管理的透皮药物输送系统用于精神分裂症治疗.
- 开发的IMN提供了长时间的治疗效果,并可能减少频繁医疗干预的需要.
- 这种新的方法可以显著改善治疗坚持性和精神分裂症管理中的患者结果.
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