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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

解码过敏性调制在冷阿贡等离子体处理的素中的解码过敏性调制:一项多学科探索.

Ruiyi Cai¹, Chin-Ping Tan², Oi-Ming Lai³

¹Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.

Journal of agricultural and food chemistry

|March 6, 2025

概括

冷血 (CAP) 通过改变其结构并改善肠道健康,有效降低素 (CN) 的过敏性. 这种创新的方法显示了通过调节免疫反应和肠道微生物群来管理食物过敏的希望.

关键词:

KU81212 的意思是什么?过敏原性过敏原性卡西因 (casein) 是一种蛋白质.冰冷的阿贡等离子体.我们的肠道菌群是肠道菌群.代谢组代谢组的代谢鼠标模型鼠标模型鼠标模型转录组 (transcriptome) 是一个转录组.

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科学领域:

食品科学食品科学食品科学
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

素 (CN) 是一种主要的牛奶过敏原.
食物过敏对健康构成重大挑战.
开发新的策略来减少食物过敏性至关重要.

研究的目的:

评估冷血 (CAP) 对素 (CN) 过敏性的影响.
通过使用多体经济学方法来调查潜在机制.
评估CAP处理的CN在控制食物过敏方面的治疗潜力.

主要方法:

使用KU812细胞进行体外评估.
在BALB/c小鼠模型中的体内研究.
多基因组学分析:16S rDNA 测序,血清代谢学,阴转录基因学.

主要成果:

CAP治疗减少了CN诱导的KU812细胞脱粒化.
小鼠的过敏反应得到缓解,转向Th1免疫主导.
用CAP治疗的CN恢复了肠道微生物群平衡,并增加了有益细菌.
多组学揭示了对脂质代谢的影响,并将Zbp1和Hbb-bt确定为潜在的调节者.

结论:

冷血 (CAP) 是减少素 (CN) 过敏性的可行方法.
CAP对免疫反应,肠道微生物群和新陈代谢产生多方面的影响.
这为食品过敏管理提供了一个有前途的创新策略.