在运动前后,在马匹中进行宁-氨-阿尔多斯特系统剖析
Todd Holbrook1, Jorge Hernandez1, Taralyn McCarrel1
1College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Journal of veterinary internal medicine
|March 6, 2025
概括
运动可以激活马的古典和替代性氨酸 - 血管酶 - 氨系统 (RAAS) 途径. 这两种途径都显示在体力炼后代谢物和酶活性增加.
科学领域:
- 马类生理学 马类生理学
- 心血管研究的心血管研究.
- 内分泌学 在内分泌学.
背景情况:
- 运动对马的氨酸-血管酶-氨系统 (RAAS) 的影响在很大程度上仍未得到研究.
- 了解RAAS通路对运动的反应对于马的健康和表现至关重要.
研究的目的:
- 为了确定运动是否激活马匹的经典和替代RAAS通路.
- 为了比较耐力和高强度运动之间的经典RAAS路径的激活.
主要方法:
- 25匹马的血液样本在四种不同的运动方案之前和之后被采集.
- 用平衡分析测量RAAS途径的血清代谢物和酶活性.
- 进行了运动前和运动后值的比较,以及不同运动组之间的比较.
主要成果:
- 在所有马匹中,运动显著增加了经典RAAS代谢物 (angiotensin I, angiotensin II, aldosterone) 和替代RAAS代谢物 (angiotensin 1-7, angiotensin 1-5).
- 血管氨酸转化酶-2的活性也在运动后显著增加.
- 与耐力 (A-E) 和跑步机运动 (TB-TM) 相比,在经历短时间,高强度赛车 (TB-R) 的马中,血管新生素1-7比率显著更高.
结论:
- 经典和替代RAAS通路都通过运动激活马.
- 运动显著影响RAAS代谢物水平和酶活性.
- 不同的运动类型可能会在RAAS中引起不同的反应,特别是关于替代途径.
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