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Updated: May 24, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
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Published on: April 23, 2016

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针对LINE-1目标的逆转录的结构机制

George E Ghanim1, Hongmiao Hu1, Jerome Boulanger1

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Science (New York, N.Y.)
|March 6, 2025
PubMed
概括

人类长间隔元素-1 (LINE-1) 逆转移体使用针对性逆转录 (TPRT). 克里奥-EM结构揭示了ORF2p动态和DNA重塑,揭示了PCNA等因素如何调节LINE-1的逆转换.

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