相关实验视频
Updated: May 8, 2025

07:42
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
118
发生性败血症住院的风险因素中的性别差异:使用英国生物银行进行的一项前性队列研究
Gary K K Low1,2, Katie Harris3, Mark Woodward3,4
1Nepean Blue Mountain Local Health District, New South Wales, Australia.
The Journal of infectious diseases
|March 6, 2025
概括
败血症住院的风险在慢性疾病中更高,特别是在患有慢性肺炎,脱脂症,心肌梗塞和吸烟的妇女中. 了解这些性别特异性风险有助于有针对性的预防和早期治疗.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 败血症是全球死亡的一个重要原因.
- 慢性疾病和生活方式因素会增加败血症的风险.
- 败血症住院风险因素的性别差异仍未得到充分探索.
研究的目的:
- 为了调查性病败血症住院的性别特异性风险因素.
- 为了确定男性和女性之间的差异性风险因素影响.
主要方法:
- 对490,783名年龄在40-69岁之间的参与者进行了前性队列研究 (英国生物银行,2006-2010年).
- 通过住院记录发现的败血症.
- 考克斯的比例危险模型用于估计性别特定的危险比率 (HRs) 和女性对男性的HRs比率 (RHR).
主要成果:
- 男性的整体败血症住院风险高于男性 (40.2/10,000人年) 与女性 (31.2/10,000).
- 慢性阻塞性肺病 (COPD) 的风险最高,对女性的影响更大 (RHR 1.23).
- 女性患有脂质不良症 (RHR 1.08),心肌梗塞 (RHR 1.22) 和吸烟 (RHR 1.19) 的风险增加. 男性的痴呆风险增加了一倍 (HR 2.21).
结论:
- 大多数危险因素增加了败血症住院的风险,女性对COPD,脂质不良,心肌梗塞和吸烟的效果放大.
- 将性别特异性风险因素纳入预测模型可以增强有针对性的预防和早期干预策略.
相关概念视频
Factors Affecting the Risk of Infection
10.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.5K
Healthcare Associated Infections II: Preventive Measures
2.3K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.3K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
3.8K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
3.8K
Pneumonia I: Introduction
169
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
169
Panic Disorder
15
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
15
Asepsis
2.0K
The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
2.0K

