黑色素通过增强肠道屏障功能和调节断奶小猪的微生物群来缓解T-2毒素诱导的肠道损伤
You Wu1, Wenguang Xiao1, Bo Xiao1
1Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Journal of agricultural and food chemistry
|March 6, 2025
概括
黑色素 (MT) 通过减少氧化应激和炎症来保护小猪免受T-2毒素引起的肠损伤. 这种保护与有益的肠道微生物群变化和短链脂肪酸 (SCFA) 增加有关.
科学领域:
- 毒理学 毒理学 毒理学
- 动物科学动物科学
- 微生物学 微生物学
背景情况:
- T-2毒素是一种虫菌毒素,对动物健康构成重大风险,特别影响胃肠道.
- 黑激素 (MT) 是一种具有已知的抗氧化和抗炎性能的激素,具有潜在的治疗应用.
- 黑素减轻T-2毒素诱导的肠毒性的特定机制需要进一步阐明.
研究的目的:
- 调查黑激素 (MT) 对断奶后小猪T-2毒素诱导的肠毒性的预防作用.
- 探索氧化应激,炎症和肠道微生物群在美拉托尼保护作用中的作用.
主要方法:
- 断奶后的猪仔被用作模型来评估T-2毒素暴露的影响.
- 黑素 (MT) 作为预防性治疗.
- 评估包括生长性能,肠道屏障功能,结肠氧化应激和炎症标志物,肠道微生物组成和短链脂肪酸 (SCFA) 水平.
主要成果:
- 黑素 (MT) 给药改善了受T-2毒素挑战的小猪的生长性能.
- MT增强了肠道屏障功能,减少了结肠氧化应激和炎症.
- 这些改善与MT诱导的肠道微生物群变化和肠道SCFA水平增加有关.
结论:
- 黑色素 (MT) 有效地减轻小猪的T-2毒素诱导的肠损伤.
- 保护机制包括减少氧化应激和炎症.
- 肠道微生物群的调节和增加的SCFA生产是美拉托尼有益作用的关键媒介.
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