基线物理和认知功能与多发性硬化症 (MS) 患者的耻辱的纵向轨迹有关
Mahsa Ghajarzadeh1, Yishang Huang1, Ellen M Mowry1
1Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21218-2625, USA.
Multiple sclerosis and related disorders
|March 6, 2025
概括
多发性硬化症 (MS) 的耻辱感遵循稳定的轨迹,由基线身体残疾和处理速度预测. 了解这些模式对于管理MS至关重要.
科学领域:
- 神经学 神经学
- 心理社会健康 心理健康
- 慢性疾病管理 慢性疾病管理
背景情况:
- 多发性硬化症 (MS) 是一种慢性,异质的神经疾病.
- 患有多发性硬化症的个体的生活经历有很大的差异.
- 了解像耻辱感这样的心理社会因素对于全面的MS护理至关重要.
研究的目的:
- 分析MS的纵向耻辱轨迹.
- 为了确定与这些耻辱轨迹相关的基线预测因素.
- 检查耻辱轨迹和身体残疾进展之间的关系.
主要方法:
- 利用了MS合作伙伴推进技术和健康解决方案 (MS PATHS) 网络的数据.
- 应用基于群体的轨迹建模 (GBTM) 来测量纵向的耻辱感 (Neuro-QoL) 和身体残疾 (PDDS).
- 包括8404名参与者,平均随访时间为2.8年.
主要成果:
- 在随访期间确定了四种不同的,稳定的耻辱轨迹.
- 较高的基线身体残疾 (PDDS) 和较差的处理速度预测了更高的耻辱轨迹.
- 耻辱的轨迹与身体残疾 (PDDS) 轨迹密切相关.
结论:
- 基线耻辱严重程度,身体残疾和处理速度是MS中长期耻辱轨迹的关键预测因素.
- 这些发现突显了MS的心理社会和身体方面的相互联系.
- 告知干预措施以减轻耻辱和支持患有MS的个体.
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