生命早期肠道抵抗体和移动体的动态:一个元分析
Ahmed Bargheet1, Hanna Theodora Noordzij2, Alise J Ponsero3
1Host-Microbe Interaction Research Group, Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway; Center for New Antibacterial Strategies, UiT The Arctic University of Norway, Tromsø, Norway.
EBioMedicine
|March 6, 2025
概括
婴儿肠道微生物因出生方式,妊娠年龄和位置而具有更多的抗生素耐药性基因 (ARG). 随着婴儿的成熟,大肠杆菌的丰富度下降,减少ARG和质粒.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 婴儿肠道微生物群表现出比成年人更高的抗生素耐药性基因 (ARG),而不论抗生素暴露.
- 围产期因素对ARG,移动遗传元素 (MGE) 和婴儿肠道中的细菌宿主的影响尚不清楚.
研究的目的:
- 调查围产期因素如何塑造婴儿肠道抵抗体和移动体.
- 确定关键的细菌宿主和参与婴儿ARG传播的遗传元素.
主要方法:
- 在MEDLINE和Embase的系统文献搜索中,对婴儿队列研究进行了枪式元基因组测序.
- 分析了来自1270名婴儿和415名母亲的3981个元基因组样本,跨越14个纵向队列.
- 综合生物信息分析以评估ARG,MGE和细菌宿主.
主要成果:
- 出生方式,妊娠年龄,抗生素使用和地理位置显著影响了婴儿肠道抗性和移动性轨迹.
- 观察到ARG多样性和丰度的地理差异;母乳养没有显著影响.
- 大肠杆菌被确定为一个关键的调节器,ARG经常在婴儿期逐渐丢失的等离子体上同定位.
结论:
- 围产期因素极大地影响婴儿肠道抵抗体和移动体的发育.
- 大肠杆菌的相对丰度下降是随着时间的推移,婴儿肠道中抗体和质粒的减少的主要驱动因素.
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