来自肌肉发育综合征患者的单细胞通过CD200/CD200R通路抑制自然杀手细胞介导的抗瘤功能

Yixuan Guo1, Zhaoyun Liu1, Mengyue Tian1

  • 1Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, PR China; Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin 300052, PR China; Tianjin Institute of Hematology, Tianjin 300052, PR China.

概括

骨髓质疏松症候群 (MDS) 患者单细胞CD200升高与预后不佳相关. 阻止这种CD200增强了自然杀手 (NK) 细胞的激活和细胞毒性,这表明MDS的潜在治疗策略.

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