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阿斯巴甜的消费与延迟青春期和线粒体功能障碍有关:来自人类和动物研究的证据

Yang-Ching Chen¹, Zih Ling Wang², Yu-Fang Lin²

¹Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan.

The Journal of nutritional biochemistry

|March 6, 2025

概括

阿斯巴甜的消费可能会延迟女性的青春期开始. 对老鼠和人类的研究表明,阿斯巴甜会破坏荷尔蒙通路和线粒体功能,可能会影响生殖发育.

科学领域:

内分泌学在内分泌学.
生殖生物学生殖生物学
毒理学毒理学毒理学

背景情况:

青春期的时间对生殖健康至关重要.
人工甜味剂,如阿斯巴甜,被广泛消费.
阿斯巴甜的潜在内分泌干扰作用需要调查.

研究的目的:

调查阿斯巴甜对女性青春期时间的影响.
在动物模型中探索潜在的生物机制.
评估阿斯巴甜摄入量与人类女孩青春期之间的关联.

主要方法:

人类队列研究 (台湾青春期纵向研究,2018-2022) 涉及858名女孩 (年龄6-12岁).
使用Sprague Dawley大鼠暴露于不同剂量的阿斯巴甜 (30-60毫克/公斤) 产前和产后的动物模型.
评估下垂体-垂体-腺 (HPG) 轴的功能,线粒体动态和青春期的开始.

主要成果:

阿斯巴甜破坏了大鼠的HPG轴,诱导线粒体功能障碍和减少卵巢线粒体生物发生,导致青春期延迟.
人类数据显示,更高的阿斯巴甜摄入与早期青春期风险降低相关 (OR=0.63,CI=0.42-0.96).
一个显著的趋势 (p=0.03) 表明,随着阿斯巴甜的摄入量增加,对早期青春期有保护作用.

结论:

长期消费阿斯巴甜可能会延迟女性的青春期开始.
阿斯巴甜对HPG轴和卵巢线粒体的影响需要进一步研究.
研究结果表明,需要更新关于青春期前女孩的阿斯巴甜的饮食指南.

关键词:

亚斯巴甜胺是一种迟到的青春期延迟的青春期雌性后代是老鼠的雌性后代.线粒体功能障碍线粒体功能障碍氧化应激是一种氧化应激.

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