对抗COVID-19的氨酸- ангиотензин系统的调节:一个前进的道路?
Serge Camelo1, Waly Dioh1, J Pedro Teixeira2
1Biophytis, Sorbonne Université, Paris, France.
概括
研究人员探索调节氨酸 - 血管素系统 (RAS) 以治疗COVID-19. 虽然许多试验是中立的,但有些人显示出希望,为急性肺损伤治疗提供了洞察力.
科学领域:
- 肺部病理学 肺部病理学
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- SARS-CoV-2 病毒与血管酶转化酶2结合,这可能解释了COVID-19 症状.
- 雷宁-血管酶系统 (RAS) 被研究为COVID-19的治疗点.
- 在之前的呼吸道病毒感染和急性呼吸道应急综合征中,RAS调节显示出有前途.
研究的目的:
- 审查和分析随机临床试验 (RCT),评估RAS调节器对严重的COVID-19进行评估.
- 在这些试验的临床意义上达成共识,并确定影响不同结果的因素.
- 分享知识,以便在其他形式的急性肺损伤中潜在应用.
主要方法:
- 合作审查涉及选定的RCT的赞助商和主要研究人员.
- 测试经典RAS臂的阻断剂和替代RAS途径的刺激剂的RCT的分析.
- 关于试验结果和影响因素的共识建设讨论.
主要成果:
- 大多数研究COVID-19RAS调节的RCT产生中性结果.
- 一些研究成功满足了其主要终点,表明了潜在的疗效.
- 在各个试验中观察到不同的结果,需要对影响因素进行进一步调查.
结论:
- 重新平衡RAS是一种复杂的策略,用于严重的COVID-19与混合试验结果.
- 了解试验差异背后的因素对于临床应用至关重要.
- 这些RCT的洞察力可能会为急性肺损伤的未来治疗提供信息.
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