TGFβ1在人类肺膜中产生一种亲纤维蛋白质,这种蛋白质对药物干预敏感

相关实验视频

Updated: May 24, 2025

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
06:02

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

12.1K

Colleen B Maxwell1, Panayiota Stylianou2, Hilary Marshall2

  • 1Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular BRC, Glenfield Hospital, University of Leicester, Leicester, UK; Leicester van Geest MultiOMICS Facility, Hodgkin Building, University of Leicester, Leicester, UK.

European journal of pharmacology
|March 6, 2025
PubMed
概括

转化生长因子β1 (TGFβ1) 在人类肺组织中诱导纤维化蛋白质组,这种蛋白质组可以被新型抗纤维化药物向. 这项研究验证了一种用于选潜在IPF治疗的蛋白质组模型.

关键词:
人体组织模型的ex vivo模型.人类蛋白质组的人类蛋白质组.异形性肺纤维化症 异形性肺纤维化症离子通道的离子通道KCa3.1 的时间.肺组织的肺组织.转化增长因子β的转化增长因子β.

更多相关视频

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

12.7K
Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.2K

相关概念视频

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.5K