[鼓膜给药的进展及其在内耳疾病治疗中的应用]
1Department of Otorhinolaryngology Head and Neck Surgery，the First Hospital of Jilin University，Changchun，130021，China.
概括
内服药通过直接输送药物,绕过血迷宫屏障,提高了内耳疾病的治疗效果. 未来的进展有望为像Meniere这样的疾病提供更精确,更安全的治疗选择.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 内耳疾病 (Meniere病,突然聋) 带来复杂的挑战,治疗效果有限.
- 目前的治疗方法由于血液迷宫屏障而扎,阻碍了有效的药物输送.
- 当地药物配送提供了一个有希望的战略,以克服这些局限性.
研究的目的:
- 综述门内药的历史发展,机制和技术优势.
- 分析葡萄糖皮质激素和 gentamicin 等药物在内耳疾病治疗中的治疗效果.
- 讨论这种药物输送方法的当前局限性和未来前景.
主要方法:
- 审查关于入管内药的现有文献.
- 在临床环境中分析药物应用效应 (葡萄糖皮质类药物, gentamicin).
- 讨论包括药物吸收,生物可用性和剂量控制在内的挑战.
主要成果:
- 内服药绕过了血液迷宫屏障,增加了局部药物度.
- 对于Meniere病,突然聋和与免疫相关的内耳疾病有明显的治疗益处.
- 在药物吸收,生物可用性和个性化剂量方面发现了限制.
结论:
- 内服药是一种有效的局部药物输送方法,用于内耳疾病.
- 纳米技术和精密医学的进步有望提高其精度和安全性.
- 这种方法有可能为内耳疾病患者提供优化治疗策略.
相关概念视频
01:14Assessing Body Temperature - Tympanic membrane
556
Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
556
01:16Anatomy of the Ear
7.1K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
7.1K