内动脉封闭是否会在下一次怀孕中导致妊娠高血压? 一个基于人口的研究从2008年到2017年
Yu-Lun Ku1, Ying-Yi Chen2, Yao-Hsu Yang3
1Department of Gynecology and Obstetrics, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Early Childhood Care and Education, Shu-Zen Junior College of Medicine and Management, Kaohsiung City, Taiwan.
Taiwanese journal of obstetrics & gynecology
|March 6, 2025
概括
怀孕前内动脉封闭并没有增加妊娠期高血压风险. 然而,它与更高的胎盘并发症,死胎和早产风险有关.
科学领域:
- 生殖医学 生殖医学
- 血管外科 血管外科
- 产科 产科 产科 产科 产科
背景情况:
- 动物模型表明,内动脉封闭 (IIAO) 可能导致妊娠高血压.
- IIAO对人类怀孕结果的影响仍然在很大程度上是未知的.
研究的目的:
- 研究先前内动脉封闭与人类妊娠高血压风险之间的关联.
- 评估IIAO对各种怀孕和新生儿后果的影响.
主要方法:
- 使用台湾出生和医疗保险数据库 (2008-2017) 进行的回顾性队列研究.
- 确定了286名在怀孕前患有IIAO的妇女 (封闭组) 和1,391,288名对照 (非封闭组).
- 分析了妊娠高血压,胎盘异常,死产和早产的风险.
主要成果:
- 两组之间妊娠高血压,孕前,孕后或HELLP综合征没有显著差异.
- 胎盘预先 (1.69),胎盘增生谱 (3.99),死产 (2.57) 在闭塞组中增加了调整后的几率比.
- 在之前IIAO的妇女中,早产的调整后几率比率显著更高 (<37周:1.48;<32周:2.79).
结论:
- 怀孕前内动脉封闭与妊娠高血压风险增加无关.
- 有IIAO病史的女性面临着胎盘前列症,胎盘增生谱,死产和早产的风险增加.
- 新生儿结局,如怀孕年龄相对较小,阿普加尔得分,出生缺陷和死亡率在各组之间相似.
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