循环环素A水平在动物模型中升高,可以预测急性胰腺炎患者的死亡率
Wenhao Cai1, Priyanka Bhattacharya2, Yuying Li3
1West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre West China Hospital, Sichuan University, Chengdu, China; Liverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
概括
循环环素A (CypA) 在实验性急性胰腺炎 (AP) 和高甘油三血症相关的AP (HTG-AP) 中升高. 患者的CypA水平升高预测了HTG-AP的严重程度和死亡风险.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 医学研究 医学研究
背景情况:
- 环素A (CypA) 在细胞损伤时释放到循环中.
- CypA水平与急性胰腺炎 (AP) 的严重程度相关.
- 有限的数据存在于循环CypA在实验AP和高甘油三血症相关的AP (HTG-AP).
研究的目的:
- 在实验AP和HTG-AP模型中研究循环CypA水平.
- 在人类队列中,特别是HTG-AP中,将CypA水平与AP严重程度和结果关联起来.
- 评估CypA对AP患者死亡率的预后价值.
主要方法:
- 在小鼠中诱导严重程度升级的急性胰腺炎 (CER-AP),使用caerulein注射.
- 通过高脂肪饮食和caerulein在子中开发实验性HTG-AP.
- 在动物模型和人类AP患者生物库中测量血清/血CypA水平.
- CypA水平与生物化学,组织病理学和临床数据的相关性,包括死亡率.
主要成果:
- 与对照人群相比,小鼠CER-AP和仓鼠HTG-AP模型中的血清CypA显著增加.
- 在HTG-AP患者中观察到的最高CypA水平,与甘油三水平和AP严重程度相关.
- 接收器操作特征 (ROC) 分析确定CypA ≥9.9 ng/ml作为死亡率的重要预测因素 (AUC = 0.865).
结论:
- 在实验AP模型中,循环CypA水平显著增加.
- 血CypA升高与HTG-AP的严重程度增加有关.
- 在AP患者中,CypA显示出预测AP患者死亡率的显著预后能力.
相关概念视频
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01:24Chronic Pancreatitis I: Introduction
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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01:27Acute Pancreatitis I: Introduction
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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