职业噪音暴露中的氧化应激标志物:系统性审查和元分析
Soheil Rahmati1,2, Sogand Sadeghi1,2, Mahmood Moosazadeh3
1Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
概括
职业噪音暴露会提高总抗氧化能力 (TAC) 和超氧化物脱酶 (SOD) 水平,这表明工人的氧化应激增加. 麦隆迪甲 (MDA) 和谷氨过氧化酶 (GPx) 水平没有显著变化,这表明对噪音的复杂反应.
科学领域:
- 职业健康 职业健康 职业健康
- 环境健康 环境健康
- 生物化学 生物化学
背景情况:
- 职业噪音暴露与不利的健康影响有关.
- 氧化应激机制与噪音引起的伤害有关.
- 调查氧化应激标志物对于了解噪音暴露影响至关重要.
研究的目的:
- 评估职业噪音对血清/血氧化应激标志物的影响.
- 为了比较高噪音暴露的工人与对照者的氧化应激标志物水平.
主要方法:
- 在PubMed,科学网和SCOPUS.com的系统文献搜索.
- 七项涉及989名工人的研究的元分析.
- 随机效应模型用于计算标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 在高噪音暴露的工人中,增加了总抗氧化能力 (TAC) (SMD,2.74) 和超氧化脱酶 (SOD) (SMD,0.90).
- 对于麦隆迪阿尔代 (MDA) 或谷氨过氧化酶 (GPx) 水平,没有观察到显著差异.
- 在各个研究中发现了很高的异质性 (I2 > 69%).
结论:
- 高度的职业噪音暴露与TAC和SOD水平的增加有关.
- 由于MDA和GPx没有显著变化,因此需要进一步研究.
- 建议采取早期检测和干预策略,以减轻与噪音相关的健康风险.
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