口腔微生物群中的抗菌素耐药性基因
1The University of Manchester, Manchester, UK. manas.dave@manchester.ac.uk.
Evidence-based dentistry
|March 6, 2025
概括
这次系统性审查绘制了口腔中的细菌抗微生物耐药性基因 (ARG). 在所有口腔部位中确定了三种ARG的核心抗体,但需要更多的研究.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 口腔内有一个复杂的微生物群,具有抗菌素耐药性基因 (ARG) 的潜在储存库.
- 了解口腔耐药性对公共卫生至关重要,因为它在抗生素耐药性传播中的潜在作用.
研究的目的:
- 系统地审查和绘制人类口腔中存在的细菌抗微生物耐药性基因 (ARG).
- 确定不同口腔部位的共同ARG,并评估各种分子技术的贡献.
主要方法:
- 进行了2015年1月至2023年8月期间发表的临床研究的系统审查.
- 研究利用聚合酶链反应 (PCR) 或下一代测序 (NGS) 的基因组学来检测口腔样本 (唾液,生物膜,纸,粘膜) 中的ARG.
- 从15项涉及1486名参与者的合格研究中提取和合成了数据.
主要成果:
- 在六个口腔区域中,发现了159种独特的ARG,对22种抗生素类别产生了耐药性.
- 超膜生物膜和唾液显示了最高的ARG丰富度,四环素和类耐药基因被广泛传播.
- 在所有采样口腔部位中发现了三种ARG的核心抗体. 国家基因系统发现的ARG和ARG携带物种明显多于PCR.
结论:
- 存在一个核心的口腔抗体,在所有口腔部位均有特定的ARG.
- 下一代测序 (NGS) 与PCR相比,可以更深入地了解口服抗体.
- 目前的研究基础有限,需要进一步进行全面研究,以充分描述口腔抗体.
相关概念视频
Antibiotic Selection
52.1K
Overview
52.1K
Genomic DNA in Prokaryotes
43.3K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.3K
Bacterial Transformation
55.0K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.0K
Antimicrobial Proteins
857
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
857
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Genome Size and the Evolution of New Genes
7.8K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.8K


