低血清丸激素水平与心血管疾病患者全因死亡率之间的关联:基于NHANES数据库的研究
1Department of General Practice, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Cardiovascular toxicology
|March 6, 2025
概括
低丸激素水平增加男性心血管疾病 (CVD) 患者的全因死亡风险. 在女性心血管疾病患者中没有发现这种关联,这表明死亡风险与性别有特定的关系.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 血清丸激素水平与包括心血管健康在内的各种健康结果有关.
- 低和心血管疾病患者死亡率之间的关系需要进一步研究,特别是考虑到性别差异.
研究的目的:
- 研究血清丸激素水平低与心血管疾病 (CVD) 的男性和女性患者全因死亡率之间的关联.
主要方法:
- 从NHANES数据库 (1999-2014) 中提取了1177名心血管疾病患者 (689名男性) 的数据.
- 低血清丸激素被定义为≤300 ng/dL.
- 用单变量和多变量考克斯回归分析来评估与所有原因死亡率的关联,计算危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 低血清丸激素水平在男性 (70.68%) 和女性 (80.74%) 心血管疾病患者中普遍存在.
- 在对共变量进行调整后,低血清丸激素与男性心血管疾病患者全因死亡风险增加显著相关 (HR = 1.48,95% CI 1.08-2.02,P = 0.013).
- 这种关联在女性心血管疾病患者中没有统计学意义.
结论:
- 低血清丸激素水平可能是患有心血管疾病的男性患者全因死亡的重要危险因素.
- 这些发现表明性别特定的关联,没有观察到低和女性心血管疾病患者死亡率之间的显著联系.
- 需要进一步的研究来探索这些性别特异性发现的潜在机制和临床影响.
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