台湾静脉血栓栓塞和炎症性肠病之间的关系:全国性的回顾性队列研究
Yi-Jen Fang1,2, Hui-Hsia Hsieh3,4, Heng-Jun Lin5
1Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan.
BMC cardiovascular disorders
|March 6, 2025
概括
患有炎症性肠病 (IBD) 的患者患有静脉血栓塞栓症 (VTE) 的风险明显更高,包括深静脉血栓症 (DVT) 和肺栓塞症 (PE). 抗IBD治疗没有改变这种风险,突显了IBD患者需要主动进行VTE管理的需要.
科学领域:
- 胃肠病学 胃肠病学
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 炎症是已知的血栓形成的危险因素,但炎症性肠病 (IBD) 中静脉血栓栓塞 (VTE) 的特定风险需要进一步阐明.
- 系统性炎症疾病与VTE有关,但与IBD的关联尚未完全确立.
研究的目的:
- 调查IBD对静脉瘤,深静脉血栓 (DVT) 和肺栓塞 (PE) 风险的影响.
- 检查抗IBD治疗对IBD患者静脉瘤风险的影响.
主要方法:
- 一项基于人口的队列研究,利用台湾国家健康保险数据库从2010-2019年.
- 考克斯比例危险回归分析用于评估VTE,DVT和PE的风险,并评估抗IBD治疗的使用.
主要成果:
- 与对照组相比,患有IBD的患者对VTE (5.58),DVT (5.48) 和PE (4.96) 的调整危险比率 (aHR) 显著提高.
- 男性IBD患者和50岁以下的患者表现出明显增加的VTE风险 (aHR分别为8.54和15.75).
- 抗IBD治疗没有显著改变静脉瘤风险;然而,口服类固醇使用 (≤80mg) 与静脉瘤发病率较低相比,IV类固醇 (aHR 0.24).
结论:
- 患有IBD的患者面临着相当高的VTE风险,特别是DVT和PE.
- 目前的抗IBD疗法没有显著影响修改VTE风险.
- 对静脉瘤风险因素的积极管理和密切的患者监测对于在IBD患者中预防静脉瘤至关重要.
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