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基于位置的BRAF V600E突变状态和零星甲状腺结节的尺寸模式:基于人口的研究

Hui Tang¹, Dan Guo^2,3, Bin Yang^4,5

¹Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. huitang0905@zju.edu.cn.

|March 6, 2025

概括

精细针吸收 (FNA) 有助于皮肤状甲状腺癌 (PTC) 的诊断. 这项研究将BRAF V600E突变与右侧结节联系起来,发现更大的瘤和更年轻的患者具有突变.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

精细针吸收 (FNA) 是乳头甲状腺癌 (PTC) 诊断的标准,可同时进行细胞学和遗传检测.
BRAF V600E突变对PTC具有高度特异性和敏感性,但其与通过FNA的成像特征的相关性尚未得到研究.

研究的目的:

为了研究BRAF V600E基因型与超声波 (美国) 成像特征 (位置,直径) 在大量甲状腺结节队列中的关系.
在PTC中探索结节横向性,BRAF V600E状态和淋巴结转移 (LNM) 之间的潜在关联.

主要方法:

针对甲状腺结节进行FNA的4808名患者的回顾性分析.
对2430名患者进行了BRAF V600E突变的分子测试.
FNA,BRAF V600E状态,美国发现 (位置,直径) 和LNM的相关性.

主要成果:

甲状腺结节主要在右侧 (p=0.0004),在贝塞斯达VI细胞学中患病率更高 (p=0.0041).
右侧的PTC显示出较高的ipsilateral LNM发生率 (p=0.0007).
BRAF V600E突变结节和右叶结节显着更大 (p=0.0156);突变阳性患者更年轻.

结论:

结节位置,特别是右侧位置,与PTC和LNM模式有关.
BRAF V600E突变与较大的结节大小和较年轻的患者年龄相关,表明不同的瘤特征.

关键词:

这就是BRAF.精细的针吸入精细的针.淋巴结转移 (LNM) 是指淋巴结转移.最大的直径最大直径.乳头甲状腺癌 (PTC) 是一种乳头甲状腺癌.这就是为什么 TERTTT.甲状腺结节甲状腺结节

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