格陵兰岛与制药有关的中毒事件
Kim Dalhoff1,2, Johanne Mølby Hansen1, Søren Bøgevig1
1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Basic & clinical pharmacology & toxicology
|March 6, 2025
概括
格陵兰经历了更严重的中毒,主要是来自,主要来自医疗保健专业人员的电话. 与丹麦相比,调查还涉及较少的儿童,突出了独特的毒理学模式.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 格陵兰和丹麦之间的中毒风险和治疗方法可能因药物可用性,种族和医疗保健准入的差异而有所不同.
- 丹麦毒素信息中心 (DPIC) 作为两个地区毒理信息的数据来源.
研究的目的:
- 使用DPIC数据,将格陵兰和丹麦中毒事件的毒理学概况进行比较.
- 为了确定常见物质的差异,中毒严重程度,呼叫者的人口统计数据和患者年龄组.
主要方法:
- 在2007年至2022年期间,对从格陵兰向DPIC提交的1827份调查进行了回顾性分析.
- 格陵兰和丹麦之间的中毒数据比较,重点关注物质频率,严重程度和患者人口统计数据.
- 统计分析以确定显著差异.
主要成果:
- 降醇是格陵兰最常见的中毒剂,其次是ibuprofen和quetiapine.
- 与丹麦 (12%) 相比,格陵兰的中度或危及生命的中毒率明显高 (36%).
- 来自格陵兰的电话主要来自医疗保健专业人员,与丹麦相比,关于儿童 (0-4岁) 的电话较少,但更多是关于年轻人 (20-29岁) 的电话.
结论:
- 格陵兰和丹麦的中毒概况存在显著差异.
- 格陵兰的医疗保健专业人员报告说,严重中毒的负担更高,特别是涉及.
- 针对格陵兰的特定人口群体,可能需要针对性的公共卫生干预措施和中毒预防策略.
更多相关视频
11:28Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose Herpestes Auropunctatus Sera for Use as an Oral Rabies Vaccination Biological Marker
Published on: May 31, 2019
5.8K
12:05Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
Published on: March 6, 2013
14.1K
相关概念视频
Prevention of Further Absorption of Poison
777
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
777
Enhanced Elimination of Poison
468
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
468
Pharmacovigilance
764
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
764
Antidotes
603
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
603
Anticholinesterase Agents: Poisoning and Treatment
772
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
772
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
