针对性治疗治疗口腔潜在恶性疾病的管理:系统性审查
Lauren Frenzel Schuch1, Fábio Muradás Girardi2,3, Laura Borges Kirschnick4
1Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo, Uruguay.
Oral diseases
|March 7, 2025
概括
向治疗对口腔潜在恶性疾病 (OPMDs) 的疗效有限. 需要进行进一步的临床试验,以确定这些精确治疗是否可以改善组织学结果或减少疾病进展.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔潜在恶性疾病 (OPMDs) 代表口腔癌发展的重大风险.
- 目前OPMD的管理策略需要进一步优化.
- 向疗法为新型OPMD治疗方法提供了潜在的途径.
研究的目的:
- 系统地审查和分析现有的关于针对性治疗对管理OPMD的影响的文献.
- 阐明用于OPMD治疗的各种向药物的疗效和安全性.
主要方法:
- 一个全面的系统审查,遵循PRISMA 2020指南.
- 在五个数据库中进行电子搜索,没有日期限制,更新于2024年1月.
- 包括专注于OPMD基于精度的向治疗的临床试验.
主要成果:
- 确定了6项美国临床试验 (12-150名参与者).
- 评估了诸如塞莱科克西布,埃洛提尼布,塞图西马布,甲胺和尼沃卢马布等药物.
- 没有观察到组织学或体型的统计学显著改善;一些患者经历了进展和与治疗有关的毒性.
结论:
- 目前的证据不支持针对性治疗用于OPMD管理的常规使用.
- 额外的精心设计的临床试验对于确定针对性治疗在OPMD中真正的潜力至关重要.
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