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脂质转移蛋白过敏的诊断和管理-A BSACI临床实践声明
Susana Marinho1,2, Marina Frleta-Gilchrist3, Hannah Hunter4,5
1Allergy Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
概括
脂质转移蛋白 (LTP) 过敏在英国越来越多地在儿童和成年人中被诊断出来,通常会引起中度到严重的反应. 由于各种触发因素和辅助因素,管理层需要个性化咨询.
科学领域:
- 食物过敏研究 食物过敏研究
- 临床免疫学 临床免疫学
- 过敏的流行病学.
背景情况:
- 花粉食物综合症 (PFS) 是英国最常见的植物食物过敏.
- 脂质转移蛋白 (LTP) 敏感化是植物食物过敏的新兴原因,在地中海地区普遍存在.
- LTPs是各种植物食品中发现的热稳定蛋白质,通常会引起严重反应.
研究的目的:
- 调查英国LTP过敏的患病率和特征.
- 为制定LTP过敏管理的临床实践陈述提供信息.
- 收集北欧LTP过敏的流行病学数据.
主要方法:
- 英国过敏和临床免疫学会 (BSACI) 进行了一项调查.
- 对英国发表的LTP过敏病例系列的分析.
- 对诊断标准和管理策略的审查.
主要成果:
- 在英国所有地区,LTP过敏在儿童和成年人中都被诊断出来.
- 常见的触发因素包括树木坚果,花生,水果,番茄和加工食品.
- 过敏反应很常见,通常与运动或酒精等辅助因素有关.
- 与地中海同行相比,英国患者对树和草花粉的敏感性更高.
- 诊断需要将阳性LTP过敏原测试与临床病史相关联.
结论:
- 在英国,LTP过敏是一个显著且日益关注的问题.
- 有效的管理需要个性化的咨询,以防止不必要的食物排斥和减轻辅助因素风险.
- 由于可能出现严重反应,应考虑使用上腺素自注射器.
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