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Updated: May 23, 2025

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在原子层面上对人类P-糖蛋白的基质流量进行建模

Yingjie Gao1, Yang Tang1, Caiyan Wei1

  • 1Green Pharmaceutical Technology Key Laboratory of Luzhou City, Department of Medicinal Chemistry, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.

Journal of biomolecular structure & dynamics
|March 7, 2025
PubMed
概括

人类P-葡萄糖蛋白 (hP-gp) 积极地从细胞中去除药物,导致多种药物耐药性. 模拟揭示了不同的药物是如何排放的,确定了关键的分子运动和开发更好的癌症疗法的途径.

关键词:
在ABC运输器上,ABC运输器人类P-葡萄糖蛋白的人类P-葡萄糖蛋白流出机制的流出机制引导分子动力学模拟的模拟.基板转位的转位

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