糖尿病的竞争性风险分析 膀癌患者的死亡率:基于人口的研究
Shunde Wang1, Baishu Zheng2, Junjie Yang1
1Department of Urology, The ChenJiaqiao Hospital of ShaPingba District of Chongqing city, Chongqing, 401331, China.
Current cancer drug targets
|March 7, 2025
概括
患有膀癌 (BC) 的患者面临着因糖尿病 (DM) 而死亡的风险显著增加. 高龄,男性性别和某些癌症特征增加了这种风险,凸显了针对性干预的必要性.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 仅限于同时患有糖尿病和膀癌 (BC) 的人的死亡率.
- 需要特别在BC患者群体中确定糖尿病 (DM) 死亡的风险因素.
研究的目的:
- 为了确定在BC患者中DM的死亡率.
- 在被诊断为BC的个人中,确定与DM死亡率相关的风险因素.
主要方法:
- 利用了2000-2017年间诊断的BC患者的SEER数据库.
- 计算了DM死亡率的标准化死亡率 (SMR).
- 采用多变量竞争风险模型来识别风险因素,使用危险比率 (HR) 和95%信心区间 (95% CI).
主要成果:
- 分析了217,230名BC患者的数据;1,783人经历了DM死亡率.
- 在BC患者中,DM的总体SMR死亡率为3.32 (95%CI:3.17-3.48).
- 与晚年,男性性别,黑人种族,原位瘤阶段,早期诊断年份,过渡细胞癌,没有化疗/辐射和没有配偶相关的DM死亡风险更高.
结论:
- 与一般人群相比,患有BC的个体患DM死亡率的风险明显增加.
- 识别高风险群体对于实施有针对性的DM干预措施至关重要.
- 有效的干预措施可以提高糖尿病BC患者的生存率.
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