预测双胞胎妊娠中不良周产期结果:一个多中心队列研究
Veronica Giorgione1, Mariarita Trapani2, Miriam Lopian1
1Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
概括
预测二双胞胎怀孕的不良结果至关重要. 结合胎儿估计体重 (EFW) 和动脉脉动指数 (PI) 不一致性,可以有效地确定死产或早产早产的风险.
科学领域:
- 产周医学 产周医学
- 孕产妇和胎儿的医学
- 高风险怀孕管理高风险怀孕管理
背景情况:
- 双胞胎双胞胎怀孕面临着死产和早产早产的高风险.
- 准确预测周产期不良结果对于及时干预至关重要.
研究的目的:
- 评估胎儿估计体重 (EFW) 和多普勒指数对二双胞胎不良周产期结果的预测值.
- 开发一个预测模型,用于死产或医学上指示的早产早产 (ePTB).
主要方法:
- 对1294例二生双胞胎怀孕的回顾性多中心队列研究.
- 在出生后两周内对胎儿估计体重 (EFW) 不一致性和多普勒指数 (动脉PI,中脑动脉PI) 的分析.
- 单变量和多变量分析以评估预测准确性.
主要成果:
- 在4.5%的怀孕中发生了不良周产期结局.
- 在受影响和未受影响的双胞胎之间,在妊娠年龄小的胎儿,EFW异调,动脉 (UA) PI异调和中脑动脉PI异调中观察到显著的差异.
- 结合EFW异调和UA PI异调的模型显示出高预测准确度 (AUC=0.90).
结论:
- 相互交织的EFW和UA PI异调的整合有效地预测死胎或医学上指示的ePTB.
- 这种预测模型在二妊娠中提供了风险分层的潜力.
- 建议进行进一步的外部验证,以完善针对性的干预措施并改善临床结果.
关键词:
有不利的围产期结局.估计的胎儿体重胎儿生长限制 限制胎儿生长相互交织的不一致性在子宫内死亡.中脑动脉中脑动脉多重怀孕是一个多重怀孕.死亡出生,死亡出生.双胞胎怀孕 双胞胎怀孕是什么带动脉是指带动脉.更多相关视频
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