肠道微生物群在长期COVID中的作用:对免疫功能和器官系统健康的影响
Angelie Pathak1, Devendra K Agrawal1
1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
概括
长期的COVID症状源于SARS-CoV-2破坏血管激素转化酶2 (ACE2),导致肠道失调和-血管激素系统 (RAS) 失衡. 本综述探讨了这些与器官功能障碍和慢性炎症的联系,用于治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- SARS-CoV-2 感染降低了血管酶转化酶2 (ACE2) 的调节,这对肠道微生物群和-血管酶系统 (RAS) 恒温至关重要.
- 降低ACE2调节会破坏肠道微生物群的多样性和RAS功能,导致长期的COVID病理生理学.
- 长期COVID症状多样化,影响多个器官系统,并与慢性炎症有关.
研究的目的:
- 审查SARS-CoV-2感染引起的失调及其对器官系统的长期影响.
- 在长期COVID中调查肠道微生物群,免疫功能和器官系统之间的双向相互作用.
- 确定针对长期COVID的微生物群失调的治疗策略.
主要方法:
- 关于SARS-CoV-2感染,ACE2,肠道微生物群,RAS和长期COVID的研究的文献评论.
- 分析ACE2下调对肠道微生物群和RAS的影响.
- 探索微生物群失调在慢性炎症和器官功能障碍中的作用.
主要成果:
- 由SARS-CoV-2感染引起的ACE2下调导致肠道失调和RAS中断.
- 微生物群的失调导致肌肉骨,神经,脏,呼吸系统和心血管系统的慢性炎症和功能障碍.
- 失衡与广泛的长期COVID症状有关,包括疲劳,脑雾和疼痛.
结论:
- 了解肠道微生物群,ACE2,RAS和免疫功能之间的相互作用对于长期的COVID至关重要.
- 准微生物群失调是缓解长期COVID症状和器官损伤的有希望的治疗途径.
- 对这些相互作用的进一步研究可以指导长期COVID患者开发有效干预措施.
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