在活体脏捐献之前的短期禁食具有免疫调节效应
Christiaan A J Oudmaijer1,2,3, Daphne S J Komninos2,3, Rutger A Ozinga2,3
1Erasmus MC Transplant Institute, Department of Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Frontiers in immunology
|March 7, 2025
概括
短期禁食 (STF) 改变免疫细胞种群,减少T细胞激活,增加B细胞. 这些变化表明对免疫细胞发育和功能的潜在影响,需要进一步的临床研究.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢健康 代谢健康
- 细胞生物学 细胞生物学
背景情况:
- 短期禁食 (STF) 是一种饮食干预,可以减少卡路里摄入量而不会导致营养不良.
- STF旨在增强对急性压力因素的系统性弹性,如手术和缺血-再输液损伤.
- 以前的研究表明,STF影响循环免疫细胞数量和表型.
研究的目的:
- 研究STF对各种免疫细胞群的丰富性和表型的影响.
- 确定STF如何影响T细胞,B细胞,树突细胞 (DC) 和髓状细胞.
主要方法:
- 利用了FAST临床试验的数据,包括30名活体脏捐赠者随机分为STF或对照组.
- 在外周血液单核细胞上采用流细胞计,以分析免疫细胞表型.
- 使用三个不同的面板检查T细胞,B细胞,DC细胞和髓状细胞的存在和激活状态.
主要成果:
- STF显著改变了免疫细胞特征,降低了T细胞的丰度和激活,包括调节性T细胞 (Tregs).
- 观察到原始B细胞的增加以及1型常规树突细胞 (cDC1s) 的增加.
- 观察到中央记忆T细胞的减少,以及各组葡萄糖,胰岛素和β-基酸盐水平的显著差异.
结论:
- STF诱导B细胞,T细胞和DC细胞发生显著的变化,倾向于较少专业化的淋巴细胞.
- 观察到的免疫学转变表明B细胞和T细胞发育的潜在停止.
- 需要进一步的研究来阐明这些禁食诱导的免疫细胞变化的临床影响和意义.
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