肠道微生物群调节了IBS所涉及的内脏敏感性,这种敏感性是由限制与尾巴聚类相结合的IBS引起的
Na Deng1,2, Siqin Xie1, Qin Liu1
1College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in cellular and infection microbiology
|March 7, 2025
概括
束与尾巴压力相结合,有效地模拟了小鼠的生气性肠综合征 (IBS). 这种压力影响肠道微生物群,短链脂肪酸 (SCFA) 和血清素 (5-HT),可能有助于IBS的发展.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 刺激性肠综合征 (IBS) 的发病过程复杂,涉及压力和肠道微生物群失调.
- 建立可靠的动物模型对于理解IBS机制和开发治疗方法至关重要.
研究的目的:
- 为了比较三个压力刺激,以获得最佳的刺激性肠综合征 (IBS) 鼠标模型创建.
- 研究肠道微生物群在压力下IBS发展中的作用.
主要方法:
- 三组小鼠 (束应力,尾巴应力,联合应力) 与对照组进行了比较.
- 评估行为变化,肠道功能,炎症标志物 (5-HT,IL-10,TNF-α) 和肠道微生物群组成 (16S rRNA测序).
主要成果:
- 综合压力最有效地诱导了IBS类症状,包括过度反应和肠道功能的改变.
- 压力诱导肠道微生物群失调,细菌种类和通路发生显著变化.
- 短链脂肪酸 (SCFA) 和血清素 (5-HT) 水平与IBS症状和炎症相关.
结论:
- 结合的束和尾部紧张是诱导IBS小鼠模型的优越方法.
- 肠道细菌如Acinetobacter和Akkermansia可能通过SCFA和5-HT调节影响IBS.
相关概念视频
Irritable Bowel Syndrome I: Introduction
215
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
215
Drugs for Treatment of Diarrhea-Predominant IBS
134
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
134
Irritable Bowel Syndrome III: Medical and Nursing Management
135
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
135
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
104
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
104
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
291
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
291
Chronic Bowel Disorders: Introduction
375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
375


