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Updated: May 23, 2025

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
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在迷幻研究中对研究设计和安慰剂控制进行系统审查

Alexander Wen1, Nikhita Singhal2, Brett D M Jones2,3

  • 1Department of Psychiatry, University of California San Diego, La Jolla, California, USA.

Psychedelic medicine (New Rochelle, N.Y.)
|March 7, 2025
PubMed
概括

在迷幻随机对照试验 (RCT) 中,由于意识的改变,盲目化很困难. 这次审查建议使用活性安慰剂和剂量反应设计来改善盲目化并减少迷幻研究中的偏见.

关键词:
经典的迷幻药物 经典的迷幻药物与安慰剂对照的控制随机对照试验是随机对照试验.研究设计研究设计系统性审查 系统性审查

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Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
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