创伤后应激障碍作为多种自身免疫性疾病的风险因素的系统审查和元分析
Kevin Mandagere1, Savanna Stoy1, Nathan Hammerle1
1Rocky Vista University College of Osteopathic Medicine, Englewood, CO, United States.
Frontiers in psychiatry
|March 7, 2025
概括
创伤后应激障碍 (PTSD) 显著增加了患上IBD,SLE,RA和MS等自身免疫疾病的风险. 这一发现突显了心理健康和身体自身免疫性疾病之间的关键联系.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 流行病学 流行病学
- 自身免疫性疾病研究研究
背景情况:
- 创伤后应激障碍 (PTSD) 是一种与不良健康结果相关的严重精神疾病.
- 创伤后应激障碍与患慢性疾病的风险增加有关,包括自身免疫性疾病,如系统性红斑狼 (SLE),炎症性肠病 (IBD),类风湿性关节炎 (RA) 和多发性硬化症 (MS).
研究的目的:
- 对有关PTSD与自身免疫性疾病之间的关联进行流行病学研究的元分析.
- 探索潜在的神经生物学和免疫学机制是这种关联的基础.
主要方法:
- 在PubMed,SCOPUS和Cochrane Reviews数据库中系统搜索相关文章,直到2023年8月.
- 包括标准的选,质量评估和数据提取由两个独立审查员进行.
- 进行了固定和随机效应的元分析,包括对生物性别和PTSD严重程度的子组分析.
主要成果:
- 八项队列研究 (n=1,984,310) 符合纳入标准.
- 在PTSD和患自身免疫性疾病的风险增加之间发现了显著的关联 (OR=1.291,P<0.001).
- 具有统计学显著关联的特定自身免疫疾病包括IBD (OR=1.142),MS (OR=1.302),SLE,RA和甲状腺炎.
结论:
- 患有SLE,MS,RA和IBD等自身免疫疾病的风险在患有PTSD的人群中显著增加.
- 这些发现对临床实践和未来研究压力相关疾病和自身免疫性疾病的病理生理学有重大影响.
关键词:
创伤后应激障碍 (PTSD) 是一种自身免疫性疾病是一种自身免疫性疾病.炎症性肠病 (IBD) 是一种炎症性肠病.多发性硬化症 (MS) 是一种疾病.心理神经免疫学 心理神经免疫学类风湿性关节炎 (RA) 是一种系统性红斑狼 (SLE) 是一种一个创伤的创伤创伤.更多相关视频
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