患有的儿童的血清HDL-C水平:单中心回顾性研究
Hong-Li Guo1, Na Dong2, Ya-Hui Hu1
1Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in nutrition
|March 7, 2025
概括
患有的儿童的高密度脂蛋白胆固醇 (HDL-C) 水平低于健康儿童. 抗发作药物 (ASM) 可能会增加HDL-C,但的低水平需要注意.
科学领域:
- 儿科神经学 儿科神经学
- 临床化学 临床化学
- 生物化学 生化学
背景情况:
- 血清高密度脂蛋白胆固醇 (HDL-C) 在心血管健康中起着至关重要的作用.
- 是一种常见的儿童神经疾病,其对代谢概况的影响是正在进行的研究领域.
- 了解儿科的脂质概况对于全面的患者管理至关重要.
研究的目的:
- 为了比较被诊断患有的儿童和健康的儿科对照者的血清HDL-C水平.
- 确定影响儿童血清HDL-C水平的潜在因素.
- 在这个人群中评估与低HDL-C相关的脱脂症风险.
主要方法:
- 从1002名患有的儿童和127名健康儿童回顾性数据收集.
- 包括98名最近被诊断的,未经治疗的患者作为基线数据.
- 统计分析包括科尔莫戈罗夫-斯米尔诺夫,曼-惠特尼,费舍尔的精确测试,赔率比率和相关性分析.
主要成果:
- 与健康儿童相比,患有的儿童的血清HDL-C水平显著降低.
- 在患有的儿童中观察到较低的HDL-C (<1.0 mmol/L) 的更高患病率,这表明患有脱脂症的风险增加 (OR, 2.773).
- 抗发作药物 (ASM),特别是牛糖素,与增加的HDL-C水平有关;维生素D补充剂也与更高的HDL-C相关.
结论:
- 与健康同龄人相比,的儿童的血清HDL-C水平显著降低.
- 治疗ASM可以部分使HDL-C水平正常化,但的潜在降低需要临床关注.
- 诸如ASM,维生素D状况,年龄,持续时间和MRI发现等因素会影响儿科的HDL-C.
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