相关实验视频

Updated: May 23, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

TCR-NP:一种新的方法来优先考虑T细胞受体谱的网络属性

Shilpika Banerjee¹, Phi Le², Hai Yang³

¹Department of Mathematics, San Francisco State University, San Francisco, CA 94132, USA.

Statistics innovation

|March 7, 2025

概括

本研究介绍了TCR-NP,这是一种分析T细胞受体 (TCR) 网络属性的新方法. TCR-NP有效地克服了数据异质性,揭示了TCR谱系结构和临床结果之间的关系.

科学领域:

免疫学免疫学免疫学
生物信息学是一种生物信息学.
计算生物学计算生物学

背景情况:

T细胞受体 (TCR) 对抗原识别至关重要,其序列相似性影响识别范围.
可以使用网络属性分析TCR目录架构,但异质性使统计学学习复杂化.
了解TCR网络特性与疾病状态和患者特征的联系是一项挑战.

研究的目的:

开发一种可靠的方法来分析异构的TCR网络属性.
为评估TCR网络结构与临床因素之间的关系提供统计学习.
引入TCR-NP (TCR网络属性优先级) 用于聚合网络属性分析和特征选择.

主要方法:

开发了TCR-NP,一种聚合异质TCR网络属性的方法.
采用伪变量辅助的处罚组拉索模型进行分组特征选择.
引入了一种新的调整策略,使用 permutation 和伪变量,绕过传统的交叉验证.

主要成果:

通过模拟研究和现实数据分析证明了TCR-NP的有效性.
强调了拟议方法论在捕捉潜在关系方面的优势.
在选择相关的TCR网络属性方面展示了更好的性能.

结论:

TCR-NP提供了一种强大的方法来分析复杂的TCR目录数据.
该方法有效地解决了TCR网络属性的数据异质性.
TCR-NP有助于更好地理解与临床结果和患者特征相关的TCR网络属性.

更多相关视频

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Published on: July 11, 2016

相关概念视频

Diversity of Antigen Receptors

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...