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影响CAR-T细胞治疗相关并发症的影响

Mohammad Mussab Umair¹, Xun Lai², YuanBo Xue³

¹Cancer Biotherapy Center & Cancer Research Institute, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.

Frontiers in oncology

|March 7, 2025

概括

化学抗原受体 (CAR) T细胞疗法对癌症治疗有希望,但可能导致严重的副作用. 了解和管理这些毒性对于推进CAR T细胞疗法至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
细胞疗法细胞疗法

背景情况:

化学抗原受体 (CAR) T细胞疗法已证明对各种癌症具有显著的疗效.
CAR T细胞治疗的临床应用与一系列不良事件有关,其严重程度各不相同.
诸如瘤负担和淋巴细胞减少等因素会影响副作用的发生和强度.

研究的目的:

提供与CAR T细胞治疗相关的不良事件的管理策略的全面概述.
阐明与CAR-T细胞相关的毒性背后的假定致病机制.
讨论在CAR T细胞治疗中减轻不良事件的当前和新兴方法.

主要方法:

对CAR T细胞治疗毒性的当代管理策略的文献综述.
分析分子途径和治疗干预措施,以减轻不良事件.
综合有关短期和慢性不良事件的当前知识.

主要成果:

常见的毒性包括细胞因子释放综合征 (CRS),免疫效应细胞相关的神经毒性综合征 (ICANS),心脏毒性等.
有效的管理策略包括了解分子通路,氨酸抑制剂,IL-6受体对抗剂,类固醇和氧化合成酶抑制.
最近的进展有可能减轻不良事件的致命后果.

结论:

对CAR T细胞疗法毒性的全面理解和管理对于患者的安全至关重要.
对分子途径和新疗法的持续研究是开发更安全的CAR T细胞治疗方法的关键.
未来的CAR T细胞疗法可能将纳入先进的策略来克服毒性挑战,改善患者的治疗结果.

关键词:

在CAR T细胞中.在CRS中,您可以使用CRS.对CAR-T的负面影响免疫疗法免疫疗法神经学毒性神经学毒性

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