肺状细胞癌和腺癌之间的外科手术期间炎症指数差异及其预后影响
Yi Liu1, Songping Cui1, Jing Wang1,2
1Department of Thoracic Surgery, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Frontiers in oncology
|March 7, 2025
概括
术后炎症指数如SIRI和PLR在肺癌类型之间存在差异,并预测结果. 这些标记物对于评估肺癌患者静脉血栓塞栓症风险和无病生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 手术病理学手术病理学
背景情况:
- 外科手术期间的炎症指数反映了全身炎症,并与癌症进展有关.
- 肺状细胞癌 (LSCC) 和肺腺癌 (LUAD) 可能表现出不同的炎症特征.
- 了解这些差异对于预测患者的结果至关重要.
研究的目的:
- 为了比较LSCC和LUAD之间的外科手术期间的炎症指数.
- 调查这些指数与长期结果的关联,包括无病生存率 (DFS) 和整体生存率 (OS).
- 确定外科手术期间静脉血栓栓塞 (VTE) 的独立风险因素.
主要方法:
- 对287名接受治愈切除术的肺癌患者进行了回顾性分析 (61名LSCC,226名LUAD).
- 收集外科手术前基线数据和炎症细胞计数.
- 随访时间中位数为76个月,记录了DFS和OS.
- 对于预后意义的考克斯回归分析.
主要成果:
- 在LSCC和LUAD之间白细胞计数和全身炎症反应指数 (SIRI) 的显著差异 (P <0.05).
- 静脉瘤的独立风险因素包括年龄,术后1日D-二次数和血小板与淋巴细胞的比率 (PLR).
- DFS的独立风险因素是开放式手术方法,LSCC瘤类型和PLR.
结论:
- 外科手术期间的炎症指数是肺癌患者外科手术期间静脉瘤的显著预测指标.
- 炎症指数,特别是PLR,对于预测肺癌无病存活率 (DFS) 来说至关重要.
- 这些发现强调了炎症标志物在肺癌管理中的预后重要性.
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