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在皮层的西塔节律的性变态与青春期内在化症状的升高有关
Nathan M Petro1,2, Giorgia Picci1,2, Lauren R Ott1
1Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, United States.
Imaging neuroscience (Cambridge, Mass.)
|March 7, 2025
概括
患有更多内化症状的青少年女孩随着年龄的增长,表现出较弱的theta大脑活动,特别是在特定的大脑区域. 这一发现可能与反和青春期女孩患精神疾病的风险更高有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 精神疾病通常在青春期出现,女孩比男孩有更高的风险.
- 精神疾病中的性别差异与发展中的关联区域中的结构性大脑差异有关.
- 功能性大脑活动与青少年精神疾病之间的联系尚不清楚.
研究的目的:
- 研究典型发育的青少年内化/外化症状和自发神经活动之间的关系.
- 探索性如何调节症状,年龄和神经活动之间的关联.
主要方法:
- 磁脑电图 (MEG) 在休息期间记录了105名青少年 (9-15岁,54名女性) 的自发皮质活动.
- 多谱自发神经活动强度估计在整个皮质.
- 纵向回归分析了症状,年龄和神经活动之间的性别调节关系.
主要成果:
- 在theta频段中发现了性别,年龄和内化症状之间的显著相互作用.
- 活动随着年龄的增长而降低,女孩具有更高的内化症状,但男孩没有.
- 这种效应最突出地出现在关节和带带皮层,涉及关联皮层.
结论:
- 自发的theta活动是由性别,年龄和青少年关联皮层内在化症状调节的.
- 老年女孩内化症状的活动减少可能反映出与焦虑和抑郁症相关的反.
- 这突显了一个潜在的神经生物学机制,导致青少年女孩患上精神疾病的发病率更高.
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