同步前列腺癌和直肠癌的发病率上升趋势:一个基于人口的研究
Elias Edfelt1, Mehrnoosh Shahrivar2, Karin Holmsten3
1Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Acta oncologica (Stockholm, Sweden)
|March 7, 2025
概括
在过去二十年中,同步前列腺癌和直肠癌的发病率在瑞典显著增加. 这一趋势凸显了潜在的过度诊断和对优化临床管理策略的需求.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 关于同步前列腺癌和直肠癌的时间趋势的数据有限.
- 为了解决这一知识差距,进行了基于人口的队列研究.
研究的目的:
- 评估同步前列腺癌和直肠癌发病率的时间趋势.
- 为了比较同步前列腺癌的发病率与一般前列腺癌的发病率.
主要方法:
- 使用了瑞典癌症登记 (1993-2019) 对发生前列腺癌的成年男性.
- 计算的年龄标准化发病率 (ASIR) 和同步与一般发病率比率 (IRR).
- 通过同步前列腺癌和非标质结肠癌进行了敏感性分析.
主要成果:
- 在238,252例前列腺癌病例中,确定了594例同步前列腺癌和直肠癌.
- 在1993-2001年和2011-2019年期间,同步前列腺癌的平均ASIR从418/100,000增加到788/100,000.
- 前列腺癌同步至一般的IRR从1.92增加到2.61,表明相对发病率上升.
结论:
- 在过去的20年里,同步前列腺癌和直肠癌的发病率在瑞典逐渐增加.
- 没有观察到发病率趋势的平原,这表明正在发生的变化.
- 需要进一步的研究来了解前列腺癌的过度诊断,并完善这些患者的治疗方法.
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