探索引人入胜的关系:表心脂肪组织与左心房和左心室功能之间的相关性,跨不同类型的心力衰竭
Zhen Wang1, Kun D Chen1, Chen Y Jin2
1Ultrasound Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.
Minerva cardiology and angiology
|March 7, 2025
概括
副心脏脂肪组织 (EAT) 的厚度因心力衰竭类型而异,在HFpEF中最高. 增加的EAT与HFpEF中的心脏功能较差有关,但在HFrEF和HFmrEF中功能改善.
科学领域:
- 心脏病学 心脏病学
- 心脏生理学 心脏生理学
- 医疗成像医学成像
背景情况:
- 心脂肪组织 (EAT) 越来越多地被认为对心血管健康的作用.
- 它与心力衰竭 (HF) 的关联需要了解它对不同HF表型的影响.
研究的目的:
- 为了研究心表脂肪组织 (EAT) 与心脏功能之间的关系.
- 分析心力衰竭与保留射出分数 (HFpEF),心力衰竭与中等射出分数 (HFmrEF) 和心力衰竭与减少射出分数 (HFrEF) 之间的这种联系.
主要方法:
- 心声学参数,包括左心室 (LV) 全球纵向应变 (GLS) 和左心房 (LA) 应变,在121名高风患者和33名对照组中进行了评估.
- 测量了心上脂肪组织 (EAT) 的厚度.
- 多变量线性回归分析了EAT和心脏功能指标之间的相关性,并调整了混因素.
主要成果:
- 在EAT和LV射出分数 (LVEF),GLS和LA菌株之间发现了非线性关系.
- 在HFpEF (7.9±0.8毫米) 中,EAT厚度最高,其次是对照组 (5.1±0.6毫米),HFmrEF (4.6±0.9毫米) 和HFrEF (4.0±0.7毫米).
- 在HFpEF中,更厚的EAT与较差的LV和LA功能相关,而在HFrEF和HFmrEF中,它与功能改善相关.
结论:
- 脊心脂肪组织 (EAT) 的厚度遵循的模式是HFpEF > 控制 > HFmrEF > HFrEF.
- 虽然较厚的EAT在HFpEF中对心脏功能有害,但它在HFrEF和HFmrEF中显示出保护性关联.
- 左心房 (LA) 功能在HFmrEF和HFrEF中比HFpEF更受损害.
相关概念视频
Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
Imbalances in Cardiac Output
1.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K
Location and Orientation of the Heart
2.2K
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
2.2K
Layers of the Heart Wall
2.1K
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
2.1K


