毒素A型时机效率在贝尔麻后同步症患者中
Abdurrahman Al-Awady1, Vivek Annadata1, Ryan Sicard1
1Divison of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
概括
早期的肉毒毒素A型 (BoNTA) 治疗Bell's Palsy并发症协,显著改善了面部分级系统 (FGS) 评分. 虽然其他措施没有显示差异,但即时的BoNTA干预是最佳患者结果的理想选择.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 整形外科 整形外科 整形外科
背景情况:
- 面部肌肉运动的异构动作 (synkinesis) 通常在贝尔之后发生.
- 甲型玻尿酸毒素 (BoNTA) 是一种常见的合成治疗方法.
- 对于同动症患者的BoNTA治疗的最佳时间尚不清楚.
研究的目的:
- 为了研究BoNTA治疗时间对患者在协同运动中的结果的影响.
- 为了确定早期干预是否与延迟治疗相比产生更好的结果.
主要方法:
- 在2016年至2022年期间在城市学术医疗中心治疗的67名协同运动患者的回顾性图表审查.
- 收集的数据包括程序笔记,干预日期,以及来自House-Brackmann (HB),面部临界测评 (Facial Clinimetric Evaluation, FaCE),同运动评估问卷 (Synkinesis Assessment Questionnaire, SAQ) 和面部分级系统 (FGS) 的分数.
- 根据治疗时间对患者进行分组:在12个月内,13-24个月内,以及24个月后的后.
主要成果:
- 在治疗时间组之间没有观察到HB,FaCE或SAQ得分变化的显著差异.
- 在麻发作1年内接受BoNTA的患者在FGS得分 (36.3) 中表现出明显更大的改善,与以后的治疗组相比 (P=.03).
- 患者的中位数年龄为54岁,治疗时平均持续时间为5.7年.
结论:
- 早期的BoNTA治疗 (在1年内) 与显著更好的结果相关,根据FGS得分测量在同步症患者中的结果.
- 虽然HB,FaCE和SAQ得分没有根据时间表显示出显著差异,但FGS的改善表明早期干预有好处.
- 这些发现表明,在协同运动开始后立即开始BoNTA治疗是最大限度地提高患者反应和功能改善的理想选择.
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