更年期对益生菌瘤的演变有有益的影响. 一项针对99名患者的研究
Stefan Matei Constantinescu1, Caterina Maria Nava1, Fanny Chasseloup2
1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
The Journal of clinical endocrinology and metabolism
|March 7, 2025
概括
更年期对患有前乳腺瘤的女性有益,有助于多巴胺激动剂的戒断. 大多数绝经后的妇女在停止治疗后实现持续缓解,很少有轻微的复发.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 在瘤学瘤学.
背景情况:
- 益生菌瘤的管理通常涉及多巴胺激动剂 (DA) 治疗.
- 更年期被假定可以改善前乳腺瘤的结果,并促进DA戒断.
- 目前,有限的证据支持更年期在益乳瘤治疗中的有益作用.
研究的目的:
- 为了研究更年期对益生菌瘤进展的影响.
- 在绝经后的女性中,评估多巴胺激素抑制剂撤销后的前乳腺瘤复发率.
主要方法:
- 对99名用多巴胺激动剂治疗的孕乳瘤妇女进行了回顾性分析.
- 从两个高等学术医院收集的数据.
- 经期更年期以异常和荷尔蒙标准来定义;记录瘤特征.
主要成果:
- 在接受稳定的DA剂量的女性中,在绝经后观察到的益生菌水平和瘤大小的显著降低.
- 56名妇女 (57%) 成功停止了多巴胺激动剂治疗,其中73%实现了持续缓解.
- 复发发生在27%的女性中,主要是在第一年内,早期戒断后的益生菌水平预测复发.
结论:
- 更年期积极影响益生菌瘤的演变,并有助于成功地戒除多巴胺激动剂.
- 三分之二的符合条件的绝经后妇女可以实现持续缓解.
- 戒断后的复发通常是轻微的和无症状的.
相关概念视频
Menopause
112
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
112
Hormonal Regulation of the Menstrual Cycle
255
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
255
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Signs of Puberty
200
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
200
Disorders of the Female Reproductive System
290
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
290
Hormonal Control of the Ovarian Cycle
372
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
372


