沙特儿童中非综合征性面孔裂的危险因素
Najla S Alrejaye1,2,3, Mostafa A Abolfotouh4,5, Fathima Fazrina Farook2,3
1Department of Dental Services, Division of Orthodontics, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Clinical and experimental dental research
|March 7, 2025
概括
沙特儿童的非综合征性口腔口腔裂 (NSOFCs) 的关键危险因素是口腔口腔裂的家族病史和怀孕期间的母体发烧. 父亲家族史显示与NSOFCs最强的关联.
科学领域:
- 医学遗传学 医学遗传学
- 儿科健康 儿科健康
- 公共卫生 公共卫生
背景情况:
- 非综合性口腔口腔裂 (NSOFCs) 是一种常见的先天性异常.
- 识别风险因素对于预防和早期干预策略至关重要.
研究的目的:
- 确定与沙特儿童非综合征性口腔裂 (NSOFCs) 相关的危险因素.
- 提供对沙特人口中NSOFCs病因学的见解.
主要方法:
- 进行了一项病例控制研究,将接受NSOFC的儿童与健康对照进行比较.
- 使用经过验证的问卷调查的家长采访收集了有关潜在风险因素的数据.
- 统计分析,包括赔率比率和置信区间,确定了重要的关联.
主要成果:
- 怀孕期间产妇发烧与NSOFCs的风险更高有关 (OR=3.4).
- 患有口腔裂的母亲亲属增加了风险 (OR=6.02).
- 父亲亲戚有口腔裂代表了最强的预测因素 (OR=8.00).
结论:
- 怀孕早期的口腔裂和母亲发烧的家族病史是NSOFCs的显著预测因素.
- 父亲有口腔裂病史是发现的最强有力的危险因素.
- 这些发现有助于理解和潜在地防止沙特阿拉伯的NSOFC.
相关概念视频
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Pedigree Analysis
83.7K
Overview
83.7K
Sex-linked Disorders
99.7K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
99.7K
Cystic Fibrosis: Pathogenesis
174
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
174
Teeth
282
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
282
Assessment of the Mouth
122
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
122


