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在艾滋病毒感染者的程序条件下,尿液代谢物决定的异化附着性

S A Nabity¹, A D Moffitt², K Mponda³

¹Division of TB Elimination, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

|March 7, 2025

概括

在高结核病-艾滋病毒环境中,艾滋病毒感染者 (PLHIV) 生物识别对伊索尼亚预防治疗 (IPT) 的遵守率低于最佳. 酒精消费与不遵守有关,突出了改善结核病预防的可修改风险因素.

科学领域:

公共卫生公共卫生
传染病流行病学传染病流行病学
艾滋病毒/艾滋病管理

背景情况:

在艾滋病毒感染者 (PLHIV) 中,对预防结核病 (TB) 具有至关重要的作用.
在高结核病负担地区的现实世界程序条件下,关于结核病预防遵守的数据有限.
优化对IPT的遵守对于降低弱势群体结核病发病率至关重要.

研究的目的:

评估PLHIV在编程环境中对每日异化 (INH) 预防治疗 (IPT) 的生物识别遵守情况.
为了确定与不遵守IPT相关的因素,尽管自我报告的摄入.
为了评估测定INH代谢物检测颜色测定试验的可靠性.

主要方法:

用色度测试检测了PLHIV的尿液INH代谢物,PLHIV在24小时内自我报告了INH摄入.
多变量日志双项回归识别了与非坚持相关的特征.
在三个独立的运营商中评估了对代谢物检测的互操作员可靠性.

主要成果:

生物识别粘附率低于最佳,INH代谢物在68.7%的PLHIV患者中被检测到,这些人自我报告了摄入.
在INH非附加PLHIV患者中,酒精消耗显著更高 (aPR 2.43).
对于INH代谢物检测的操作者间可靠性是中度到强度 (κ 0.860.94).

结论:

在高结核病-艾滋病毒环境中,对IPT的生物识别遵守率低于自我报告的遵守率.
酒精消费是与INH不坚持相关的显著可修改的风险因素.
颜色测量试验证明了可靠的性能,用于监测IPT遵守.

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