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Updated: May 23, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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用Cinnarizine抑制阿尔多的评估,这是一种假定的Cav1.3抑制剂

Elisabeth Ng1,2, Yun-Ni Lee1,2, Angela Taylor3

  • 1Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

The Journal of clinical endocrinology and metabolism
|March 7, 2025
PubMed
概括

作为Cav1.3通道连接体的cinnarizine在体外降低了阿尔多素分泌,但在患有初级阿尔多素主义 (PA) 的患者中,它的效果不如尼菲迪平的效果. 临床试验表明,在PA患者中,辛纳瑞并没有降低血中阿尔多与素的比率 (ARR).

关键词:
阿尔多斯氨酸是一种阿尔多斯氨酸.通道阻塞剂 通道阻塞剂辛纳利辛 (Cinarizine) 是一种一种尼菲迪平因 (nifedipine) 是一种尼菲迪平因 (nifedipine) 的一种药物.主要的阿尔多斯顿主义.

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