肠道微生物群的改变与小鼠的亚临床甲状腺功能低下和脂质失调有关
Ru Wang1, Xiaqing Yu1, Haidong Cai1
1Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
概括
小鼠的亚临床甲状腺功能低下症 (SCH) 并没有显著改变肠道微生物群的组成,但肠道失生症恶化了甲状腺功能,与失脂症相关,这表明微生物群在SCH管理中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 人们越来越认识到肠道微生物群在甲状腺疾病中的作用,但其与亚临床甲状腺功能低下症 (SCH) 的特定联系需要进一步调查.
- 现有的研究不足以充分阐明肠道微生物群落与SCH的发展或进展之间的关系.
研究的目的:
- 在小鼠模型中探索肠道微生物群组成和亚临床甲状腺功能低下症 (SCH) 之间的潜在关系.
- 在SCH.的背景下调查肠道微生物群和脂质失调症之间的关联.
- 评估肠道微生物群不平衡对SCH中的甲状腺功能的影响.
主要方法:
- 亚临床甲状腺功能低下症 (SCH) 和脂质失调症在小鼠中被诱导使用methimazole.
- 用16S rRNA基因测序分析了肠道微生物组成.
- 用抗生素诱导的肠道微生物群破坏来评估其对甲状腺功能的影响.
主要成果:
- 在SCH和对照小鼠之间没有观察到Firmicutes/Bacteroidota比率或α-多样性的显著差异.
- 两组之间检测到β多样性的微小但明显的差异.
- 确定了14个不同的肠道属,与SCH小鼠的血清脂质水平有显著的相关性.
- 肠道微生物群的不平衡加剧了抗生素治疗的SCH小鼠的甲状腺功能低下症.
结论:
- 亚临床甲状腺功能低下症 (SCH) 在早期阶段似乎不会引起显著的肠道微生物群失调.
- 肠道微生物群在调节甲状腺功能的过程中起着至关重要的作用,并且与SCH.的失脂症密切相关.
- 这些发现为通过向肠道微生物群来管理SCH患者的失脂症提供了新的视角.
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