相关实验视频

Updated: Jul 8, 2026

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.4K

使用联合虚拟查策略发现一种具有高抑制功率的新型PLK1抑制剂

Zhen Xu1, Lixia Guan2, Yuting Wang2

  • 1Department of Oncology, Urology and Reproductive Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.

Journal of enzyme inhibition and medicinal chemistry
|March 7, 2025
PubMed
概括

研究人员发现了针对针对前列腺癌治疗的Polo样酶1 (PLK1) 的强效化合物. 希特-4在癌细胞上表现出显著的PLK1抑制和抗增殖作用,显示出治疗前景.

关键词:
波罗样酶1 (PLK1) 是一种波罗样酶.停靠检查对接检查药物学家对药物学家进行查.前列腺癌 (PCa) 是一种癌症.

更多相关视频

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

9.1K
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays13:22

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

7.8K

相关概念视频

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...