相关实验视频

Updated: Jul 24, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

摄入 (多) 的生物标志物:系统性审查

Yong Li¹, Yifan Xu¹, Marilyn Nash¹

¹Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Critical reviews in food science and nutrition

|March 7, 2025

概括

经过验证的多生物标志物,如尿液中的SREM和PgVLM,显示出评估饮食摄入量和预防非传染性疾病的前景. 需要进一步的研究来克服诸如特异性和短半衰期之类的挑战.

科学领域:

营养生物化学营养生物化学
分析化学分析化学
公共卫生公共卫生

背景情况:

植物食品中的多可帮助预防非传染性疾病.
准确评估聚醇摄入量至关重要,但具有挑战性.
生物标志物为饮食回忆方法提供了一个客观的替代方案.

研究的目的:

系统地审查和评估验证的多生物标志物.
确定生物标志物有效性的关键标准.
为未来关于饮食中多醇摄入量评估的研究提供信息.

主要方法:

在三个数据库中进行系统的文献搜索 (1995-2025年).
包括使用经过验证的方法对生物流体中的生物标志物进行量化研究.
基于多个标准 (例如,特异性,剂量反应) 评估生物标志物的有效性.

主要成果:

确定了五个多代谢板,用于特定的多摄入量 (异黄,氧,甲,-3-ols).
在24小时尿液中,结构相关的 (-) - 甲基代谢物 (SREM) 和PgVLM满足了五个验证标准.
挑战包括有限的特异性,短半衰期和个体间的变异性.

结论:

SREM和PgVLM是分别对甲和黄-3-ol摄入量最有效的生物标志物.
进一步的研究是必不可少的,以提高生物标志物的有效性,以便精确的饮食评估.
需要增强生物标志物来进行关于植物性饮食和健康的强有力的流行病学研究.

关键词:

生物标志物生物标志物生物标志物验证的验证饮食中的 (多) .系统性审查系统性审查

更多相关视频

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

相关概念视频

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...