生活方式及其对多个器官系统生物衰老的相对贡献:来自中国多民族队列研究的变化分析
Yuan Zhang1, Dan Tang1,2, Ning Zhang1
1West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
eLife
|March 7, 2025
概括
健康的生活方式的改变减缓了中国西南部各器官的生物衰老. 饮食和吸烟是影响全面和代谢生物衰老加速的关键因素.
科学领域:
- 老年学与公共卫生
- 流行病学 流行病学
- 生活方式 医学 医疗
背景情况:
- 生物衰老在各个器官系统之间有所不同,但生活方式对整体和器官特定衰老的影响在中国西南地区仍未得到充分研究.
- 了解生活方式的作用对于开发有针对性的干预措施来缓解不同人群的衰老过程至关重要.
研究的目的:
- 调查中国西南地区健康生活方式指数 (HLI) 与整体/特定器官生物年龄 (BA) 加速之间的关联.
- 确定导致生物衰老的关键生活方式因素及其对综合性和器官特定BA的相对影响.
主要方法:
- 利用来自中国多民族队列 (CMEC) 研究的8396名参与者的数据,评估生活方式因素 (吸烟,酒精,饮食,运动,睡眠) 来创建HLI.
- 使用Klemera-Doubal方法计算了综合和器官特定的BA (心肺,代谢,肝脏),并根据疾病结局验证了它们.
- 采用固定效应模型和量子G计算来分析HLI/组件和BA加速之间的关联,并确定相对贡献.
主要成果:
- 大约三分之二的参与者在调查之间修改了他们的HLI分数.
- 改善的HLI与加速的综合BA (平均转班 -0.19) 和经过验证的器官特定BA显示出保护性关联.
- 饮食和吸烟成为负面关联的主要贡献者,分别对综合BA (24%) 和代谢BA (55%) 的加速产生重大影响.
结论:
- 健康的生活方式的修改与中国西南地区的综合性和器官特异性生物衰老相反相关.
- 饮食和吸烟是生物衰老的显著调节者,特别影响代谢BA.
- 结果强调了生活方式干预减缓衰老的潜力,并建议在发展中国家针对器官特定衰老的有针对性的策略.
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